Porcine epidemic diarrhea virus papain-like protease 2 can be noncompetitively inhibited by 6-thioguanine
Identifieur interne : 000C51 ( Main/Exploration ); précédent : 000C50; suivant : 000C52Porcine epidemic diarrhea virus papain-like protease 2 can be noncompetitively inhibited by 6-thioguanine
Auteurs : Hsu-Feng Chu [Taïwan] ; Chiao-Che Chen [Taïwan] ; David C. Moses [Taïwan] ; Yau-Hung Chen [Taïwan] ; Chao-Hsiung Lin [Taïwan] ; Ying-Chieh Tsai [Taïwan] ; Chi-Yuan Chou [Taïwan]Source :
- Antiviral Research [ 0166-3542 ] ; 2018.
Descripteurs français
- KwdFr :
- Antiviraux (pharmacologie), Cinétique, Conformation des protéines (), Coronavirus (), Infections à coronavirus, Papaïne (), Papaïne (antagonistes et inhibiteurs), Papaïne (génétique), Papaïne (isolement et purification), Protéines recombinantes, Simulation de docking moléculaire, Sites de fixation (), Tioguanine (pharmacologie), Virus de la diarrhée porcine épidémique (), Virus de la diarrhée porcine épidémique (génétique).
- MESH :
- antagonistes et inhibiteurs : Papaïne.
- génétique : Papaïne, Virus de la diarrhée porcine épidémique.
- isolement et purification : Papaïne.
- pharmacologie : Antiviraux, Tioguanine.
- Cinétique, Conformation des protéines, Coronavirus, Infections à coronavirus, Papaïne, Protéines recombinantes, Simulation de docking moléculaire, Sites de fixation, Virus de la diarrhée porcine épidémique.
English descriptors
- KwdEn :
- Antiviral Agents (pharmacology), Binding Sites (drug effects), Coronavirus (drug effects), Coronavirus Infections, Kinetics, Molecular Docking Simulation, Papain (antagonists & inhibitors), Papain (chemistry), Papain (genetics), Papain (isolation & purification), Porcine epidemic diarrhea virus (drug effects), Porcine epidemic diarrhea virus (genetics), Protein Conformation (drug effects), Recombinant Proteins, Thioguanine (pharmacology).
- MESH :
- chemical , antagonists & inhibitors : Papain.
- chemical , chemistry : Papain.
- chemical , genetics : Papain.
- chemical , isolation & purification : Papain.
- chemical , pharmacology : Antiviral Agents, Thioguanine.
- drug effects : Binding Sites, Coronavirus, Porcine epidemic diarrhea virus, Protein Conformation.
- genetics : Porcine epidemic diarrhea virus.
- Coronavirus Infections, Kinetics, Molecular Docking Simulation, Recombinant Proteins.
Abstract
Porcine epidemic diarrhea virus (PEDV) is a coronavirus (CoV) discovered in the 1970s that infects the intestinal tract of pigs, resulting in diarrhea and vomiting. It can cause extreme dehydration and death in neonatal piglets. In Asia, modified live attenuated vaccines have been used to control PEDV infection in recent years. However, a new strain of PEDV that belongs to genogroup 2a appeared in the USA in 2013 and then quickly spread to Canada and Mexico as well as Asian and European countries. Due to the less effective protective immunity provided by the vaccines against this new strain, it has caused considerable agricultural and economic loss worldwide. The emergence of this new strain increases the importance of understanding PEDV as well as strategies for inhibiting it. Coronaviral proteases, including main proteases and papain-like proteases, are ideal antiviral targets because of their essential roles in viral maturation. Here we provide a first description of the expression, purification and structural characteristics of recombinant PEDV papain-like protease 2, moreover present our finding that 6-thioguanine, a chemotherapeutic drug, in contrast to its competitive inhibition on SARS- and MERS-CoV papain-like proteases, is a noncompetitive inhibitor of PEDV papain-like protease 2.
Url:
DOI: 10.1016/j.antiviral.2018.08.011
PubMed: 30138642
PubMed Central: 7113753
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000D93
- to stream Pmc, to step Curation: 000D93
- to stream Pmc, to step Checkpoint: 000528
- to stream PubMed, to step Corpus: 000982
- to stream PubMed, to step Curation: 000982
- to stream PubMed, to step Checkpoint: 000978
- to stream Ncbi, to step Merge: 002F59
- to stream Ncbi, to step Curation: 002F59
- to stream Ncbi, to step Checkpoint: 002F59
- to stream Main, to step Merge: 000C53
- to stream Main, to step Curation: 000C51
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Porcine epidemic diarrhea virus papain-like protease 2 can be noncompetitively inhibited by 6-thioguanine</title><author><name sortKey="Chu, Hsu Feng" sort="Chu, Hsu Feng" uniqKey="Chu H" first="Hsu-Feng" last="Chu">Hsu-Feng Chu</name><affiliation wicri:level="1"><nlm:aff id="aff1">Biomedical Industry Ph.D. Program, National Yang-Ming University, Taipei 112, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Biomedical Industry Ph.D. Program, National Yang-Ming University, Taipei 112</wicri:regionArea><wicri:noRegion>Taipei 112</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei 112, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei 112</wicri:regionArea><wicri:noRegion>Taipei 112</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Chiao Che" sort="Chen, Chiao Che" uniqKey="Chen C" first="Chiao-Che" last="Chen">Chiao-Che Chen</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei 112, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei 112</wicri:regionArea><wicri:noRegion>Taipei 112</wicri:noRegion></affiliation></author><author><name sortKey="Moses, David C" sort="Moses, David C" uniqKey="Moses D" first="David C." last="Moses">David C. Moses</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Chemistry, Tamkang University, Tamsui 251, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Chemistry, Tamkang University, Tamsui 251</wicri:regionArea><wicri:noRegion>Tamsui 251</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Yau Hung" sort="Chen, Yau Hung" uniqKey="Chen Y" first="Yau-Hung" last="Chen">Yau-Hung Chen</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Chemistry, Tamkang University, Tamsui 251, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Chemistry, Tamkang University, Tamsui 251</wicri:regionArea><wicri:noRegion>Tamsui 251</wicri:noRegion></affiliation></author><author><name sortKey="Lin, Chao Hsiung" sort="Lin, Chao Hsiung" uniqKey="Lin C" first="Chao-Hsiung" last="Lin">Chao-Hsiung Lin</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei 112, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei 112</wicri:regionArea><wicri:noRegion>Taipei 112</wicri:noRegion></affiliation></author><author><name sortKey="Tsai, Ying Chieh" sort="Tsai, Ying Chieh" uniqKey="Tsai Y" first="Ying-Chieh" last="Tsai">Ying-Chieh Tsai</name><affiliation wicri:level="1"><nlm:aff id="aff4">Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei 112, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei 112</wicri:regionArea><wicri:noRegion>Taipei 112</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff5">Probiotic Research Center, National Yang-Ming University, Taipei 112, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Probiotic Research Center, National Yang-Ming University, Taipei 112</wicri:regionArea><wicri:noRegion>Taipei 112</wicri:noRegion></affiliation></author><author><name sortKey="Chou, Chi Yuan" sort="Chou, Chi Yuan" uniqKey="Chou C" first="Chi-Yuan" last="Chou">Chi-Yuan Chou</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei 112, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei 112</wicri:regionArea><wicri:noRegion>Taipei 112</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">30138642</idno><idno type="pmc">7113753</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113753</idno><idno type="RBID">PMC:7113753</idno><idno type="doi">10.1016/j.antiviral.2018.08.011</idno><date when="2018">2018</date><idno type="wicri:Area/Pmc/Corpus">000D93</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000D93</idno><idno type="wicri:Area/Pmc/Curation">000D93</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000D93</idno><idno type="wicri:Area/Pmc/Checkpoint">000528</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000528</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:30138642</idno><idno type="wicri:Area/PubMed/Corpus">000982</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000982</idno><idno type="wicri:Area/PubMed/Curation">000982</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000982</idno><idno type="wicri:Area/PubMed/Checkpoint">000978</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000978</idno><idno type="wicri:Area/Ncbi/Merge">002F59</idno><idno type="wicri:Area/Ncbi/Curation">002F59</idno><idno type="wicri:Area/Ncbi/Checkpoint">002F59</idno><idno type="wicri:doubleKey">0166-3542:2018:Chu H:porcine:epidemic:diarrhea</idno><idno type="wicri:Area/Main/Merge">000C53</idno><idno type="wicri:Area/Main/Curation">000C51</idno><idno type="wicri:Area/Main/Exploration">000C51</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Porcine epidemic diarrhea virus papain-like protease 2 can be noncompetitively inhibited by 6-thioguanine</title><author><name sortKey="Chu, Hsu Feng" sort="Chu, Hsu Feng" uniqKey="Chu H" first="Hsu-Feng" last="Chu">Hsu-Feng Chu</name><affiliation wicri:level="1"><nlm:aff id="aff1">Biomedical Industry Ph.D. Program, National Yang-Ming University, Taipei 112, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Biomedical Industry Ph.D. Program, National Yang-Ming University, Taipei 112</wicri:regionArea><wicri:noRegion>Taipei 112</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei 112, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei 112</wicri:regionArea><wicri:noRegion>Taipei 112</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Chiao Che" sort="Chen, Chiao Che" uniqKey="Chen C" first="Chiao-Che" last="Chen">Chiao-Che Chen</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei 112, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei 112</wicri:regionArea><wicri:noRegion>Taipei 112</wicri:noRegion></affiliation></author><author><name sortKey="Moses, David C" sort="Moses, David C" uniqKey="Moses D" first="David C." last="Moses">David C. Moses</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Chemistry, Tamkang University, Tamsui 251, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Chemistry, Tamkang University, Tamsui 251</wicri:regionArea><wicri:noRegion>Tamsui 251</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Yau Hung" sort="Chen, Yau Hung" uniqKey="Chen Y" first="Yau-Hung" last="Chen">Yau-Hung Chen</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Chemistry, Tamkang University, Tamsui 251, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Chemistry, Tamkang University, Tamsui 251</wicri:regionArea><wicri:noRegion>Tamsui 251</wicri:noRegion></affiliation></author><author><name sortKey="Lin, Chao Hsiung" sort="Lin, Chao Hsiung" uniqKey="Lin C" first="Chao-Hsiung" last="Lin">Chao-Hsiung Lin</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei 112, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei 112</wicri:regionArea><wicri:noRegion>Taipei 112</wicri:noRegion></affiliation></author><author><name sortKey="Tsai, Ying Chieh" sort="Tsai, Ying Chieh" uniqKey="Tsai Y" first="Ying-Chieh" last="Tsai">Ying-Chieh Tsai</name><affiliation wicri:level="1"><nlm:aff id="aff4">Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei 112, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei 112</wicri:regionArea><wicri:noRegion>Taipei 112</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff5">Probiotic Research Center, National Yang-Ming University, Taipei 112, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Probiotic Research Center, National Yang-Ming University, Taipei 112</wicri:regionArea><wicri:noRegion>Taipei 112</wicri:noRegion></affiliation></author><author><name sortKey="Chou, Chi Yuan" sort="Chou, Chi Yuan" uniqKey="Chou C" first="Chi-Yuan" last="Chou">Chi-Yuan Chou</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei 112, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei 112</wicri:regionArea><wicri:noRegion>Taipei 112</wicri:noRegion></affiliation></author></analytic><series><title level="j">Antiviral Research</title><idno type="ISSN">0166-3542</idno><idno type="eISSN">1872-9096</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiviral Agents (pharmacology)</term><term>Binding Sites (drug effects)</term><term>Coronavirus (drug effects)</term><term>Coronavirus Infections</term><term>Kinetics</term><term>Molecular Docking Simulation</term><term>Papain (antagonists & inhibitors)</term><term>Papain (chemistry)</term><term>Papain (genetics)</term><term>Papain (isolation & purification)</term><term>Porcine epidemic diarrhea virus (drug effects)</term><term>Porcine epidemic diarrhea virus (genetics)</term><term>Protein Conformation (drug effects)</term><term>Recombinant Proteins</term><term>Thioguanine (pharmacology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Antiviraux (pharmacologie)</term><term>Cinétique</term><term>Conformation des protéines ()</term><term>Coronavirus ()</term><term>Infections à coronavirus</term><term>Papaïne ()</term><term>Papaïne (antagonistes et inhibiteurs)</term><term>Papaïne (génétique)</term><term>Papaïne (isolement et purification)</term><term>Protéines recombinantes</term><term>Simulation de docking moléculaire</term><term>Sites de fixation ()</term><term>Tioguanine (pharmacologie)</term><term>Virus de la diarrhée porcine épidémique ()</term><term>Virus de la diarrhée porcine épidémique (génétique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Papain</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Papain</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Papain</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Papain</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term><term>Thioguanine</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Papaïne</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Binding Sites</term><term>Coronavirus</term><term>Porcine epidemic diarrhea virus</term><term>Protein Conformation</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Porcine epidemic diarrhea virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Papaïne</term><term>Virus de la diarrhée porcine épidémique</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Papaïne</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term><term>Tioguanine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Coronavirus Infections</term><term>Kinetics</term><term>Molecular Docking Simulation</term><term>Recombinant Proteins</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Cinétique</term><term>Conformation des protéines</term><term>Coronavirus</term><term>Infections à coronavirus</term><term>Papaïne</term><term>Protéines recombinantes</term><term>Simulation de docking moléculaire</term><term>Sites de fixation</term><term>Virus de la diarrhée porcine épidémique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Porcine epidemic diarrhea virus (PEDV) is a coronavirus (CoV) discovered in the 1970s that infects the intestinal tract of pigs, resulting in diarrhea and vomiting. It can cause extreme dehydration and death in neonatal piglets. In Asia, modified live attenuated vaccines have been used to control PEDV infection in recent years. However, a new strain of PEDV that belongs to genogroup 2a appeared in the USA in 2013 and then quickly spread to Canada and Mexico as well as Asian and European countries. Due to the less effective protective immunity provided by the vaccines against this new strain, it has caused considerable agricultural and economic loss worldwide. The emergence of this new strain increases the importance of understanding PEDV as well as strategies for inhibiting it. Coronaviral proteases, including main proteases and papain-like proteases, are ideal antiviral targets because of their essential roles in viral maturation. Here we provide a first description of the expression, purification and structural characteristics of recombinant PEDV papain-like protease 2, moreover present our finding that 6-thioguanine, a chemotherapeutic drug, in contrast to its competitive inhibition on SARS- and MERS-CoV papain-like proteases, is a noncompetitive inhibitor of PEDV papain-like protease 2.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Anand, K" uniqKey="Anand K">K. Anand</name></author><author><name sortKey="Ziebuhr, J" uniqKey="Ziebuhr J">J. Ziebuhr</name></author><author><name sortKey="Wadhwani, P" uniqKey="Wadhwani P">P. Wadhwani</name></author><author><name sortKey="Mesters, J R" uniqKey="Mesters J">J.R. Mesters</name></author><author><name sortKey="Hilgenfeld, R" uniqKey="Hilgenfeld R">R. Hilgenfeld</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arnold, K" uniqKey="Arnold K">K. Arnold</name></author><author><name sortKey="Bordoli, L" uniqKey="Bordoli L">L. Bordoli</name></author><author><name sortKey="Kopp, J" uniqKey="Kopp J">J. Kopp</name></author><author><name sortKey="Schwede, T" uniqKey="Schwede T">T. Schwede</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Avvakumov, G V" uniqKey="Avvakumov G">G.V. Avvakumov</name></author><author><name sortKey="Walker, J R" uniqKey="Walker J">J.R. Walker</name></author><author><name sortKey="Xue, S" uniqKey="Xue S">S. Xue</name></author><author><name sortKey="Finerty, P J" uniqKey="Finerty P">P.J. Finerty</name></author><author><name sortKey="Mackenzie, F" uniqKey="Mackenzie F">F. Mackenzie</name></author><author><name sortKey="Newman, E M" uniqKey="Newman E">E.M. Newman</name></author><author><name sortKey="Dhe Paganon, S" uniqKey="Dhe Paganon S">S. Dhe-Paganon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bacha, U" uniqKey="Bacha U">U. Bacha</name></author><author><name sortKey="Barrila, J" uniqKey="Barrila J">J. Barrila</name></author><author><name sortKey="Gabelli, S B" uniqKey="Gabelli S">S.B. Gabelli</name></author><author><name sortKey="Kiso, Y" uniqKey="Kiso Y">Y. Kiso</name></author><author><name sortKey="Mario Amzel, L" uniqKey="Mario Amzel L">L. Mario Amzel</name></author><author><name sortKey="Freire, E" uniqKey="Freire E">E. Freire</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bailey Elkin, B A" uniqKey="Bailey Elkin B">B.A. Bailey-Elkin</name></author><author><name sortKey="Knaap, R C" uniqKey="Knaap R">R.C. Knaap</name></author><author><name sortKey="Johnson, G G" uniqKey="Johnson G">G.G. Johnson</name></author><author><name sortKey="Dalebout, T J" uniqKey="Dalebout T">T.J. Dalebout</name></author><author><name sortKey="Ninaber, D K" uniqKey="Ninaber D">D.K. Ninaber</name></author><author><name sortKey="Van Kasteren, P B" uniqKey="Van Kasteren P">P.B. van Kasteren</name></author><author><name sortKey="Bredenbeek, P J" uniqKey="Bredenbeek P">P.J. Bredenbeek</name></author><author><name sortKey="Snijder, E J" uniqKey="Snijder E">E.J. Snijder</name></author><author><name sortKey="Kikkert, M" uniqKey="Kikkert M">M. Kikkert</name></author><author><name sortKey="Mark, B L" uniqKey="Mark B">B.L. Mark</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bullock, A N" uniqKey="Bullock A">A.N. Bullock</name></author><author><name sortKey="Henckel, J" uniqKey="Henckel J">J. Henckel</name></author><author><name sortKey="Dedecker, B S" uniqKey="Dedecker B">B.S. DeDecker</name></author><author><name sortKey="Johnson, C M" uniqKey="Johnson C">C.M. Johnson</name></author><author><name sortKey="Nikolova, P V" uniqKey="Nikolova P">P.V. Nikolova</name></author><author><name sortKey="Proctor, M R" uniqKey="Proctor M">M.R. Proctor</name></author><author><name sortKey="Lane, D P" uniqKey="Lane D">D.P. Lane</name></author><author><name sortKey="Fersht, A R" uniqKey="Fersht A">A.R. Fersht</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chan, J F" uniqKey="Chan J">J.F. Chan</name></author><author><name sortKey="Lau, S K" uniqKey="Lau S">S.K. Lau</name></author><author><name sortKey="To, K K" uniqKey="To K">K.K. To</name></author><author><name sortKey="Cheng, V C" uniqKey="Cheng V">V.C. Cheng</name></author><author><name sortKey="Woo, P C" uniqKey="Woo P">P.C. Woo</name></author><author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K.Y. Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chasey, D" uniqKey="Chasey D">D. Chasey</name></author><author><name sortKey="Cartwright, S F" uniqKey="Cartwright S">S.F. Cartwright</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chaudhuri, R" uniqKey="Chaudhuri R">R. Chaudhuri</name></author><author><name sortKey="Tang, S" uniqKey="Tang S">S. Tang</name></author><author><name sortKey="Zhao, G" uniqKey="Zhao G">G. Zhao</name></author><author><name sortKey="Lu, H" uniqKey="Lu H">H. Lu</name></author><author><name sortKey="Case, D A" uniqKey="Case D">D.A. Case</name></author><author><name sortKey="Johnson, M E" uniqKey="Johnson M">M.E. Johnson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, X" uniqKey="Chen X">X. Chen</name></author><author><name sortKey="Chou, C Y" uniqKey="Chou C">C.Y. Chou</name></author><author><name sortKey="Chang, G G" uniqKey="Chang G">G.G. Chang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cheng, K W" uniqKey="Cheng K">K.W. Cheng</name></author><author><name sortKey="Cheng, S C" uniqKey="Cheng S">S.C. Cheng</name></author><author><name sortKey="Chen, W Y" uniqKey="Chen W">W.Y. Chen</name></author><author><name sortKey="Lin, M H" uniqKey="Lin M">M.H. Lin</name></author><author><name sortKey="Chuang, S J" uniqKey="Chuang S">S.J. Chuang</name></author><author><name sortKey="Cheng, I H" uniqKey="Cheng I">I.H. Cheng</name></author><author><name sortKey="Sun, C Y" uniqKey="Sun C">C.Y. Sun</name></author><author><name sortKey="Chou, C Y" uniqKey="Chou C">C.Y. Chou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chou, C Y" uniqKey="Chou C">C.Y. Chou</name></author><author><name sortKey="Chien, C H" uniqKey="Chien C">C.H. Chien</name></author><author><name sortKey="Han, Y S" uniqKey="Han Y">Y.S. Han</name></author><author><name sortKey="Prebanda, M T" uniqKey="Prebanda M">M.T. Prebanda</name></author><author><name sortKey="Hsieh, H P" uniqKey="Hsieh H">H.P. Hsieh</name></author><author><name sortKey="Turk, B" uniqKey="Turk B">B. Turk</name></author><author><name sortKey="Chang, G G" uniqKey="Chang G">G.G. Chang</name></author><author><name sortKey="Chen, X" uniqKey="Chen X">X. Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chou, C Y" uniqKey="Chou C">C.Y. Chou</name></author><author><name sortKey="Lai, H Y" uniqKey="Lai H">H.Y. Lai</name></author><author><name sortKey="Chen, H Y" uniqKey="Chen H">H.Y. Chen</name></author><author><name sortKey="Cheng, S C" uniqKey="Cheng S">S.C. Cheng</name></author><author><name sortKey="Cheng, K W" uniqKey="Cheng K">K.W. Cheng</name></author><author><name sortKey="Chou, Y W" uniqKey="Chou Y">Y.W. Chou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chou, Y W" uniqKey="Chou Y">Y.W. Chou</name></author><author><name sortKey="Cheng, S C" uniqKey="Cheng S">S.C. Cheng</name></author><author><name sortKey="Lai, H Y" uniqKey="Lai H">H.Y. Lai</name></author><author><name sortKey="Chou, C Y" uniqKey="Chou C">C.Y. Chou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chuang, S J" uniqKey="Chuang S">S.J. Chuang</name></author><author><name sortKey="Cheng, S C" uniqKey="Cheng S">S.C. Cheng</name></author><author><name sortKey="Tang, H C" uniqKey="Tang H">H.C. Tang</name></author><author><name sortKey="Sun, C Y" uniqKey="Sun C">C.Y. Sun</name></author><author><name sortKey="Chou, C Y" uniqKey="Chou C">C.Y. Chou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Clasman, J R" uniqKey="Clasman J">J.R. Clasman</name></author><author><name sortKey="Baez Santos, Y M" uniqKey="Baez Santos Y">Y.M. Baez-Santos</name></author><author><name sortKey="Mettelman, R C" uniqKey="Mettelman R">R.C. Mettelman</name></author><author><name sortKey="O Brien, A" uniqKey="O Brien A">A. O'Brien</name></author><author><name sortKey="Baker, S C" uniqKey="Baker S">S.C. Baker</name></author><author><name sortKey="Mesecar, A D" uniqKey="Mesecar A">A.D. Mesecar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Clementz, M A" uniqKey="Clementz M">M.A. Clementz</name></author><author><name sortKey="Chen, Z" uniqKey="Chen Z">Z. Chen</name></author><author><name sortKey="Banach, B S" uniqKey="Banach B">B.S. Banach</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y. Wang</name></author><author><name sortKey="Sun, L" uniqKey="Sun L">L. Sun</name></author><author><name sortKey="Ratia, K" uniqKey="Ratia K">K. Ratia</name></author><author><name sortKey="Baez Santos, Y M" uniqKey="Baez Santos Y">Y.M. Baez-Santos</name></author><author><name sortKey="Wang, J" uniqKey="Wang J">J. Wang</name></author><author><name sortKey="Takayama, J" uniqKey="Takayama J">J. Takayama</name></author><author><name sortKey="Ghosh, A K" uniqKey="Ghosh A">A.K. Ghosh</name></author><author><name sortKey="Li, K" uniqKey="Li K">K. Li</name></author><author><name sortKey="Mesecar, A D" uniqKey="Mesecar A">A.D. Mesecar</name></author><author><name sortKey="Baker, S C" uniqKey="Baker S">S.C. Baker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Han, Y S" uniqKey="Han Y">Y.S. Han</name></author><author><name sortKey="Chang, G G" uniqKey="Chang G">G.G. Chang</name></author><author><name sortKey="Juo, C G" uniqKey="Juo C">C.G. Juo</name></author><author><name sortKey="Lee, H J" uniqKey="Lee H">H.J. Lee</name></author><author><name sortKey="Yeh, S H" uniqKey="Yeh S">S.H. Yeh</name></author><author><name sortKey="Hsu, J T" uniqKey="Hsu J">J.T. Hsu</name></author><author><name sortKey="Chen, X" uniqKey="Chen X">X. Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ho, B L" uniqKey="Ho B">B.L. Ho</name></author><author><name sortKey="Cheng, S C" uniqKey="Cheng S">S.C. Cheng</name></author><author><name sortKey="Shi, L" uniqKey="Shi L">L. Shi</name></author><author><name sortKey="Wang, T Y" uniqKey="Wang T">T.Y. Wang</name></author><author><name sortKey="Ho, K I" uniqKey="Ho K">K.I. Ho</name></author><author><name sortKey="Chou, C Y" uniqKey="Chou C">C.Y. Chou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, Y W" uniqKey="Huang Y">Y.W. Huang</name></author><author><name sortKey="Dickerman, A W" uniqKey="Dickerman A">A.W. Dickerman</name></author><author><name sortKey="Pineyro, P" uniqKey="Pineyro P">P. Pineyro</name></author><author><name sortKey="Li, L" uniqKey="Li L">L. Li</name></author><author><name sortKey="Fang, L" uniqKey="Fang L">L. Fang</name></author><author><name sortKey="Kiehne, R" uniqKey="Kiehne R">R. Kiehne</name></author><author><name sortKey="Opriessnig, T" uniqKey="Opriessnig T">T. Opriessnig</name></author><author><name sortKey="Meng, X J" uniqKey="Meng X">X.J. Meng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kumar, V" uniqKey="Kumar V">V. Kumar</name></author><author><name sortKey="Shin, J S" uniqKey="Shin J">J.S. Shin</name></author><author><name sortKey="Shie, J J" uniqKey="Shie J">J.J. Shie</name></author><author><name sortKey="Ku, K B" uniqKey="Ku K">K.B. Ku</name></author><author><name sortKey="Kim, C" uniqKey="Kim C">C. Kim</name></author><author><name sortKey="Go, Y Y" uniqKey="Go Y">Y.Y. Go</name></author><author><name sortKey="Huang, K F" uniqKey="Huang K">K.F. Huang</name></author><author><name sortKey="Kim, M" uniqKey="Kim M">M. Kim</name></author><author><name sortKey="Liang, P H" uniqKey="Liang P">P.H. Liang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, C" uniqKey="Lee C">C. Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, C D" uniqKey="Lee C">C.D. Lee</name></author><author><name sortKey="Sun, H C" uniqKey="Sun H">H.C. Sun</name></author><author><name sortKey="Hu, S M" uniqKey="Hu S">S.M. Hu</name></author><author><name sortKey="Chiu, C F" uniqKey="Chiu C">C.F. Chiu</name></author><author><name sortKey="Homhuan, A" uniqKey="Homhuan A">A. Homhuan</name></author><author><name sortKey="Liang, S M" uniqKey="Liang S">S.M. Liang</name></author><author><name sortKey="Leng, C H" uniqKey="Leng C">C.H. Leng</name></author><author><name sortKey="Wang, T F" uniqKey="Wang T">T.F. Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lei, J" uniqKey="Lei J">J. Lei</name></author><author><name sortKey="Hilgenfeld, R" uniqKey="Hilgenfeld R">R. Hilgenfeld</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lei, J" uniqKey="Lei J">J. Lei</name></author><author><name sortKey="Kusov, Y" uniqKey="Kusov Y">Y. Kusov</name></author><author><name sortKey="Hilgenfeld, R" uniqKey="Hilgenfeld R">R. Hilgenfeld</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lei, J" uniqKey="Lei J">J. Lei</name></author><author><name sortKey="Mesters, J R" uniqKey="Mesters J">J.R. Mesters</name></author><author><name sortKey="Drosten, C" uniqKey="Drosten C">C. Drosten</name></author><author><name sortKey="Anemuller, S" uniqKey="Anemuller S">S. Anemuller</name></author><author><name sortKey="Ma, Q" uniqKey="Ma Q">Q. Ma</name></author><author><name sortKey="Hilgenfeld, R" uniqKey="Hilgenfeld R">R. Hilgenfeld</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, C" uniqKey="Li C">C. Li</name></author><author><name sortKey="Li, W" uniqKey="Li W">W. Li</name></author><author><name sortKey="Lucio De Esesarte, E" uniqKey="Lucio De Esesarte E">E. Lucio de Esesarte</name></author><author><name sortKey="Guo, H" uniqKey="Guo H">H. Guo</name></author><author><name sortKey="Van Den Elzen, P" uniqKey="Van Den Elzen P">P. van den Elzen</name></author><author><name sortKey="Aarts, E" uniqKey="Aarts E">E. Aarts</name></author><author><name sortKey="Van Den Born, E" uniqKey="Van Den Born E">E. van den Born</name></author><author><name sortKey="Rottier, P J M" uniqKey="Rottier P">P.J.M. Rottier</name></author><author><name sortKey="Bosch, B J" uniqKey="Bosch B">B.J. Bosch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, F" uniqKey="Li F">F. Li</name></author><author><name sortKey="Li, W" uniqKey="Li W">W. Li</name></author><author><name sortKey="Farzan, M" uniqKey="Farzan M">M. Farzan</name></author><author><name sortKey="Harrison, S C" uniqKey="Harrison S">S.C. Harrison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lin, M H" uniqKey="Lin M">M.H. Lin</name></author><author><name sortKey="Chuang, S J" uniqKey="Chuang S">S.J. Chuang</name></author><author><name sortKey="Chen, C C" uniqKey="Chen C">C.C. Chen</name></author><author><name sortKey="Cheng, S C" uniqKey="Cheng S">S.C. Cheng</name></author><author><name sortKey="Cheng, K W" uniqKey="Cheng K">K.W. Cheng</name></author><author><name sortKey="Lin, C H" uniqKey="Lin C">C.H. Lin</name></author><author><name sortKey="Sun, C Y" uniqKey="Sun C">C.Y. Sun</name></author><author><name sortKey="Chou, C Y" uniqKey="Chou C">C.Y. Chou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lin, M H" uniqKey="Lin M">M.H. Lin</name></author><author><name sortKey="Moses, D C" uniqKey="Moses D">D.C. Moses</name></author><author><name sortKey="Hsieh, C H" uniqKey="Hsieh C">C.H. Hsieh</name></author><author><name sortKey="Cheng, S C" uniqKey="Cheng S">S.C. Cheng</name></author><author><name sortKey="Chen, Y H" uniqKey="Chen Y">Y.H. Chen</name></author><author><name sortKey="Sun, C Y" uniqKey="Sun C">C.Y. Sun</name></author><author><name sortKey="Chou, C Y" uniqKey="Chou C">C.Y. Chou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mielech, A M" uniqKey="Mielech A">A.M. Mielech</name></author><author><name sortKey="Kilianski, A" uniqKey="Kilianski A">A. Kilianski</name></author><author><name sortKey="Baez Santos, Y M" uniqKey="Baez Santos Y">Y.M. Baez-Santos</name></author><author><name sortKey="Mesecar, A D" uniqKey="Mesecar A">A.D. Mesecar</name></author><author><name sortKey="Baker, S C" uniqKey="Baker S">S.C. Baker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Park, J Y" uniqKey="Park J">J.Y. Park</name></author><author><name sortKey="Jeong, H J" uniqKey="Jeong H">H.J. Jeong</name></author><author><name sortKey="Kim, J H" uniqKey="Kim J">J.H. Kim</name></author><author><name sortKey="Kim, Y M" uniqKey="Kim Y">Y.M. Kim</name></author><author><name sortKey="Park, S J" uniqKey="Park S">S.J. Park</name></author><author><name sortKey="Kim, D" uniqKey="Kim D">D. Kim</name></author><author><name sortKey="Park, K H" uniqKey="Park K">K.H. Park</name></author><author><name sortKey="Lee, W S" uniqKey="Lee W">W.S. Lee</name></author><author><name sortKey="Ryu, Y B" uniqKey="Ryu Y">Y.B. Ryu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ratia, K" uniqKey="Ratia K">K. Ratia</name></author><author><name sortKey="Pegan, S" uniqKey="Pegan S">S. Pegan</name></author><author><name sortKey="Takayama, J" uniqKey="Takayama J">J. Takayama</name></author><author><name sortKey="Sleeman, K" uniqKey="Sleeman K">K. Sleeman</name></author><author><name sortKey="Coughlin, M" uniqKey="Coughlin M">M. Coughlin</name></author><author><name sortKey="Baliji, S" uniqKey="Baliji S">S. Baliji</name></author><author><name sortKey="Chaudhuri, R" uniqKey="Chaudhuri R">R. Chaudhuri</name></author><author><name sortKey="Fu, W" uniqKey="Fu W">W. Fu</name></author><author><name sortKey="Prabhakar, B S" uniqKey="Prabhakar B">B.S. Prabhakar</name></author><author><name sortKey="Johnson, M E" uniqKey="Johnson M">M.E. Johnson</name></author><author><name sortKey="Baker, S C" uniqKey="Baker S">S.C. Baker</name></author><author><name sortKey="Ghosh, A K" uniqKey="Ghosh A">A.K. Ghosh</name></author><author><name sortKey="Mesecar, A D" uniqKey="Mesecar A">A.D. Mesecar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ratia, K" uniqKey="Ratia K">K. Ratia</name></author><author><name sortKey="Saikatendu, K S" uniqKey="Saikatendu K">K.S. Saikatendu</name></author><author><name sortKey="Santarsiero, B D" uniqKey="Santarsiero B">B.D. Santarsiero</name></author><author><name sortKey="Barretto, N" uniqKey="Barretto N">N. Barretto</name></author><author><name sortKey="Baker, S C" uniqKey="Baker S">S.C. Baker</name></author><author><name sortKey="Stevens, R C" uniqKey="Stevens R">R.C. Stevens</name></author><author><name sortKey="Mesecar, A D" uniqKey="Mesecar A">A.D. Mesecar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Renatus, M" uniqKey="Renatus M">M. Renatus</name></author><author><name sortKey="Parrado, S G" uniqKey="Parrado S">S.G. Parrado</name></author><author><name sortKey="D Arcy, A" uniqKey="D Arcy A">A. D'Arcy</name></author><author><name sortKey="Eidhoff, U" uniqKey="Eidhoff U">U. Eidhoff</name></author><author><name sortKey="Gerhartz, B" uniqKey="Gerhartz B">B. Gerhartz</name></author><author><name sortKey="Hassiepen, U" uniqKey="Hassiepen U">U. Hassiepen</name></author><author><name sortKey="Pierrat, B" uniqKey="Pierrat B">B. Pierrat</name></author><author><name sortKey="Riedl, R" uniqKey="Riedl R">R. Riedl</name></author><author><name sortKey="Vinzenz, D" uniqKey="Vinzenz D">D. Vinzenz</name></author><author><name sortKey="Worpenberg, S" uniqKey="Worpenberg S">S. Worpenberg</name></author><author><name sortKey="Kroemer, M" uniqKey="Kroemer M">M. Kroemer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schuck, P" uniqKey="Schuck P">P. Schuck</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Song, D" uniqKey="Song D">D. Song</name></author><author><name sortKey="Moon, H" uniqKey="Moon H">H. Moon</name></author><author><name sortKey="Kang, B" uniqKey="Kang B">B. Kang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Song, D" uniqKey="Song D">D. Song</name></author><author><name sortKey="Park, B" uniqKey="Park B">B. Park</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stevenson, G W" uniqKey="Stevenson G">G.W. Stevenson</name></author><author><name sortKey="Hoang, H" uniqKey="Hoang H">H. Hoang</name></author><author><name sortKey="Schwartz, K J" uniqKey="Schwartz K">K.J. Schwartz</name></author><author><name sortKey="Burrough, E R" uniqKey="Burrough E">E.R. Burrough</name></author><author><name sortKey="Sun, D" uniqKey="Sun D">D. Sun</name></author><author><name sortKey="Madson, D" uniqKey="Madson D">D. Madson</name></author><author><name sortKey="Cooper, V L" uniqKey="Cooper V">V.L. Cooper</name></author><author><name sortKey="Pillatzki, A" uniqKey="Pillatzki A">A. Pillatzki</name></author><author><name sortKey="Gauger, P" uniqKey="Gauger P">P. Gauger</name></author><author><name sortKey="Schmitt, B J" uniqKey="Schmitt B">B.J. Schmitt</name></author><author><name sortKey="Koster, L G" uniqKey="Koster L">L.G. Koster</name></author><author><name sortKey="Killian, M L" uniqKey="Killian M">M.L. Killian</name></author><author><name sortKey="Yoon, K J" uniqKey="Yoon K">K.J. Yoon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Trott, O" uniqKey="Trott O">O. Trott</name></author><author><name sortKey="Olson, A J" uniqKey="Olson A">A.J. Olson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, N" uniqKey="Wang N">N. Wang</name></author><author><name sortKey="Shi, X" uniqKey="Shi X">X. Shi</name></author><author><name sortKey="Jiang, L" uniqKey="Jiang L">L. Jiang</name></author><author><name sortKey="Zhang, S" uniqKey="Zhang S">S. Zhang</name></author><author><name sortKey="Wang, D" uniqKey="Wang D">D. Wang</name></author><author><name sortKey="Tong, P" uniqKey="Tong P">P. Tong</name></author><author><name sortKey="Guo, D" uniqKey="Guo D">D. Guo</name></author><author><name sortKey="Fu, L" uniqKey="Fu L">L. Fu</name></author><author><name sortKey="Cui, Y" uniqKey="Cui Y">Y. Cui</name></author><author><name sortKey="Liu, X" uniqKey="Liu X">X. Liu</name></author><author><name sortKey="Arledge, K C" uniqKey="Arledge K">K.C. Arledge</name></author><author><name sortKey="Chen, Y H" uniqKey="Chen Y">Y.H. Chen</name></author><author><name sortKey="Zhang, L" uniqKey="Zhang L">L. Zhang</name></author><author><name sortKey="Wang, X" uniqKey="Wang X">X. Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Whitmore, L" uniqKey="Whitmore L">L. Whitmore</name></author><author><name sortKey="Wallace, B A" uniqKey="Wallace B">B.A. Wallace</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wojdyla, J A" uniqKey="Wojdyla J">J.A. Wojdyla</name></author><author><name sortKey="Manolaridis, I" uniqKey="Manolaridis I">I. Manolaridis</name></author><author><name sortKey="Van Kasteren, P B" uniqKey="Van Kasteren P">P.B. van Kasteren</name></author><author><name sortKey="Kikkert, M" uniqKey="Kikkert M">M. Kikkert</name></author><author><name sortKey="Snijder, E J" uniqKey="Snijder E">E.J. Snijder</name></author><author><name sortKey="Gorbalenya, A E" uniqKey="Gorbalenya A">A.E. Gorbalenya</name></author><author><name sortKey="Tucker, P A" uniqKey="Tucker P">P.A. Tucker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, C Y" uniqKey="Wu C">C.Y. Wu</name></author><author><name sortKey="King, K Y" uniqKey="King K">K.Y. King</name></author><author><name sortKey="Kuo, C J" uniqKey="Kuo C">C.J. Kuo</name></author><author><name sortKey="Fang, J M" uniqKey="Fang J">J.M. Fang</name></author><author><name sortKey="Wu, Y T" uniqKey="Wu Y">Y.T. Wu</name></author><author><name sortKey="Ho, M Y" uniqKey="Ho M">M.Y. Ho</name></author><author><name sortKey="Liao, C L" uniqKey="Liao C">C.L. Liao</name></author><author><name sortKey="Shie, J J" uniqKey="Shie J">J.J. Shie</name></author><author><name sortKey="Liang, P H" uniqKey="Liang P">P.H. Liang</name></author><author><name sortKey="Wong, C H" uniqKey="Wong C">C.H. Wong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, K" uniqKey="Wu K">K. Wu</name></author><author><name sortKey="Li, W" uniqKey="Li W">W. Li</name></author><author><name sortKey="Peng, G" uniqKey="Peng G">G. Peng</name></author><author><name sortKey="Li, F" uniqKey="Li F">F. Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xing, Y" uniqKey="Xing Y">Y. Xing</name></author><author><name sortKey="Chen, J" uniqKey="Chen J">J. Chen</name></author><author><name sortKey="Tu, J" uniqKey="Tu J">J. Tu</name></author><author><name sortKey="Zhang, B" uniqKey="Zhang B">B. Zhang</name></author><author><name sortKey="Chen, X" uniqKey="Chen X">X. Chen</name></author><author><name sortKey="Shi, H" uniqKey="Shi H">H. Shi</name></author><author><name sortKey="Baker, S C" uniqKey="Baker S">S.C. Baker</name></author><author><name sortKey="Feng, L" uniqKey="Feng L">L. Feng</name></author><author><name sortKey="Chen, Z" uniqKey="Chen Z">Z. Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, H" uniqKey="Yang H">H. Yang</name></author><author><name sortKey="Yang, M" uniqKey="Yang M">M. Yang</name></author><author><name sortKey="Ding, Y" uniqKey="Ding Y">Y. Ding</name></author><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y. Liu</name></author><author><name sortKey="Lou, Z" uniqKey="Lou Z">Z. Lou</name></author><author><name sortKey="Zhou, Z" uniqKey="Zhou Z">Z. Zhou</name></author><author><name sortKey="Sun, L" uniqKey="Sun L">L. Sun</name></author><author><name sortKey="Mo, L" uniqKey="Mo L">L. Mo</name></author><author><name sortKey="Ye, S" uniqKey="Ye S">S. Ye</name></author><author><name sortKey="Pang, H" uniqKey="Pang H">H. Pang</name></author><author><name sortKey="Gao, G F" uniqKey="Gao G">G.F. Gao</name></author><author><name sortKey="Anand, K" uniqKey="Anand K">K. Anand</name></author><author><name sortKey="Bartlam, M" uniqKey="Bartlam M">M. Bartlam</name></author><author><name sortKey="Hilgenfeld, R" uniqKey="Hilgenfeld R">R. Hilgenfeld</name></author><author><name sortKey="Rao, Z" uniqKey="Rao Z">Z. Rao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zheng, D" uniqKey="Zheng D">D. Zheng</name></author><author><name sortKey="Chen, G" uniqKey="Chen G">G. Chen</name></author><author><name sortKey="Guo, B" uniqKey="Guo B">B. Guo</name></author><author><name sortKey="Cheng, G" uniqKey="Cheng G">G. Cheng</name></author><author><name sortKey="Tang, H" uniqKey="Tang H">H. Tang</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Taïwan</li></country></list><tree><country name="Taïwan"><noRegion><name sortKey="Chu, Hsu Feng" sort="Chu, Hsu Feng" uniqKey="Chu H" first="Hsu-Feng" last="Chu">Hsu-Feng Chu</name></noRegion><name sortKey="Chen, Chiao Che" sort="Chen, Chiao Che" uniqKey="Chen C" first="Chiao-Che" last="Chen">Chiao-Che Chen</name><name sortKey="Chen, Yau Hung" sort="Chen, Yau Hung" uniqKey="Chen Y" first="Yau-Hung" last="Chen">Yau-Hung Chen</name><name sortKey="Chou, Chi Yuan" sort="Chou, Chi Yuan" uniqKey="Chou C" first="Chi-Yuan" last="Chou">Chi-Yuan Chou</name><name sortKey="Chu, Hsu Feng" sort="Chu, Hsu Feng" uniqKey="Chu H" first="Hsu-Feng" last="Chu">Hsu-Feng Chu</name><name sortKey="Lin, Chao Hsiung" sort="Lin, Chao Hsiung" uniqKey="Lin C" first="Chao-Hsiung" last="Lin">Chao-Hsiung Lin</name><name sortKey="Moses, David C" sort="Moses, David C" uniqKey="Moses D" first="David C." last="Moses">David C. Moses</name><name sortKey="Tsai, Ying Chieh" sort="Tsai, Ying Chieh" uniqKey="Tsai Y" first="Ying-Chieh" last="Tsai">Ying-Chieh Tsai</name><name sortKey="Tsai, Ying Chieh" sort="Tsai, Ying Chieh" uniqKey="Tsai Y" first="Ying-Chieh" last="Tsai">Ying-Chieh Tsai</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000C51 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000C51 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:7113753
|texte= Porcine epidemic diarrhea virus papain-like protease 2 can be noncompetitively inhibited by 6-thioguanine
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:30138642" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |